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The overall aim of our work is to characterise the mechanisms by which both genetically-determined and environmentally-induced alterations in central neurotransmitter function in general, and monoaminergic function in particular, contributes to the aetiology of affective disorders. Specifically, our current objectives are:
- To characterise brain function in the offspring of dams previously exposed to the psychostimulant drug “Ecstasy”.
- To characterise brain function in animals where genetic modification alters central monoaminergic, either directly or indirectly.
- To characterise the mechanisms by which altered cerebrovascular physiology might contribute to changes in brain function induced by both genetic and environmental manipulation of central monoaminergic systems.